Two New Chromones from Cassia auriculata and Their Antiviral Activity

文献类型： 外文期刊

第一作者： Liu, Xiao-Shan

作者： Liu, Xiao-Shan;Zheng, Jun-Na;Shen, Si-Yu;Li, Shan-Shan;Li, Yin-Ke;Zhou, Min;Hu, Qiu-fen;Miao, Dong;Liu, Xiao-Shan;Shen, Si-Yu;Li, Shan-Shan;Gong, Da-Ping;Xiong, Wen;Ma, Xiao-Wei;Li, Yin-Ke;Zhang, Feng-Mei

作者机构：

关键词： Cassia auriculata; chromones; anti-TMV activity; anti-rotavirus activity

期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.8； 五年影响因子：0.8 ）

ISSN： 0009-3130

年卷期： 2023 年 59 卷 3 期

页码：

收录情况： SCI

摘要： Two new chromones, 2-(2-(furan-2-yl)-2-oxoethyl)-6-methoxy-8-(2-oxopropyl)-chromone (1) and 2-(2-(furan-2-yl)-2-oxoethyl)-5-methoxy-8-(2-oxopropyl)-chromone (2), along with four known ones (3-6) were isolated from the stem bark of Cassia auriculata. The new compounds were elucidated by means of spectroscopic methods, whereas the known compounds were identified by comparison with the data in the literature. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results revealed that 1 and 2 exhibited potential anti-TMV activities with inhibition rates of 28.2 and 30.5% respectively, and these rates are close to that of the positive control. Compounds 1 and 2 were also tested for their anti-rotavirus activities, and compounds 1 and 2 showed potential activity with therapeutic index (TI) values of 14.8 and 15.9 respectively. These values are lower than that of the positive control.

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