Comparative analysis of physicochemical characteristics and in vitro biological activities of polysaccharides from gamma-irradiated and nonirradiated Schizophyllum commune

文献类型： 外文期刊

第一作者： Yin, Chaomin

作者： Yin, Chaomin;Shi, Defang;Chen, Zheya;Fan, Xiuzhi;Yao, Fen;Lu, Qi;Gao, Hong;Yin, Chaomin

作者机构：

关键词： ?-Irradiation; Polysaccharides; Antioxidant activity; Antiproliferative activity

期刊名称：RADIATION PHYSICS AND CHEMISTRY （ 影响因子：2.776； 五年影响因子：2.725 ）

ISSN： 0969-806X

年卷期： 2022 年 197 卷

页码：

收录情况： SCI

摘要： In this study, the physicochemical characteristics and in vitro biological activities of polysaccharides from gamma-irradiated (6, 12 and 18 kGy irradiation doses) and non-irradiated Schizophyllum commune (Fr.) were analyzed. The results showed that the average molecular weight significantly decreased with increasing irradiation dose, whereas the solubility was increased after irradiation. Increased total carbohydrate content, lightness and yel-lowness as well as slightly decreased thermal stability were observed with increasing irradiation dose. Irradiation treatment decreased the hydroxyl radical scavenging activity and alpha-amylase inhibitory activity, but increased the reducing power, although no dose-response relationship was observed. When compared to SPGN, SPG6 showed a higher inhibition rate toward HeLa and A549 cells, while SPG18 showed a higher inhibition rate toward HepG2 cells. Overall, SPG18 induced a higher rate of cell apoptosis in HeLa, HepG2 and A549 cells than SPGN did. These results suggested that gamma-irradiation treatment of S. commune at an appropriate dose can effectively improve the physicochemical properties and enhance the antiproliferation activity of SPGs.

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