Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity

文献类型： 外文期刊

第一作者： Lv, Jia

作者： Lv, Jia;Yang, Quan;Luo, Bi;Lv, Jia;Yang, Quan;Luo, Bi;Lv, Jia;Zhou, Hong;Zhou, Hong;Dong, Limei;Wang, Hao;Yang, Li;Yu, Haiqian;Wu, Peixi;Liang, Yongqian;Zhou, Le

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关键词： Cinnamomum cassia; endophytic fungus; secondary metabolites; Hypoxylon vinosopulvinatum; antifungal activity

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.2； 五年影响因子：2.3 ）

ISSN： 1478-6419

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Hypoxylon vinosopulvinatum DYR-1-7 is a endophytic fungus isolated from the Cinnamomum cassia Presl and has an inhibitory effect on Lasiodiplodia pseudotheobromae. Three new furanones, hypoxylonone A-C (1-3), as well as three known compounds (4-6), were isolated from an EtOAc extract of H. vinosopulvinatum DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of 1- 3 were elucidated by electronic circular dichroism (ECD) analyses. In the antifungal bioassay, Hypoxylonone B and C exhibited strong inhibitory effects on L. pseudotheobromae with IC50 value at the concentration of 1.01 and 2.40 mu g/mL, respectively. Compound 6 showed medium antifungal activity with IC50 value at the concentration of 10.67 mu g/mL on Fusarium oxysporum. Compounds 3 and 4 displayed medium antifungul effects on Candida albicans.

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