Stimuli-responsive biodegradable silica nanoparticles: From native structure designs to biological applications

文献类型： 外文期刊

第一作者： Qi, Qianhui

作者： Qi, Qianhui;Wang, Wei;Shen, Qian;Geng, Jiaying;An, Weizhen;Wu, Qiong;Yu, Changmin;Shen, Qian;Geng, Jiaying;An, Weizhen;Wu, Qiong;Yu, Changmin;Qi, Qianhui;Yu, Changmin;Wang, Nan;Zhang, Yu;Li, Xue;Li, Lin

作者机构：

关键词： Biodegradation; Silica nanoparticles; Stimuli -responsive; Multiple frameworks; Biological applications

期刊名称：ADVANCES IN COLLOID AND INTERFACE SCIENCE （ 影响因子：15.6； 五年影响因子：14.8 ）

ISSN： 0001-8686

年卷期： 2024 年 324 卷

页码：

收录情况： SCI

摘要： Due to their inherent advantages, silica nanoparticles (SiNPs) have greatly potential applications as bioactive materials in biosensors/biomedicine. However, the long-term and nonspecific accumulation in healthy tissues may give rise to toxicity, thereby impeding their widespread clinical application. Hence, it is imperative and noteworthy to develop biodegradable and clearable SiNPs for biomedical purposes. Recently, the design of multistimuli responsive SiNPs to improve degradation efficiency under specific pathological conditions has increased their clinical trial potential as theranostic nanoplatform. This review comprehensively summaries the rational design and recent progress of biodegradable SiNPs under various internal and external stimuli for rapid in vivo degradation and clearance. In addition, the factors that affect the biodegradation of SiNPs are also discussed. We believe that this systematic review will offer profound stimulus and timely guide for further research in the field of SiNP-based nanosensors/nanomedicine.

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