Multifunctional chitosan-hydroxyapatite-polyphenol nanoparticles from 3D printed bone scaffolds: Controlled release and therapeutic properties

文献类型： 外文期刊

第一作者： Chen, Jiafang

作者： Chen, Jiafang;Zhao, Shuyi;Dai, Lingna;Liu, Jiancheng;Li, Sanqiang;He, Jian;Yang, Mingchuan;Zhang, Xiangchun;Qiao, Liang;Fu, Qizhi;Guo, Juanjuan

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关键词： MRSA; Macrophage polarization; 3D-printed scaffolds; Immunomodulatory; Osteogenic differentiation

期刊名称：EUROPEAN POLYMER JOURNAL （ 影响因子：6.3； 五年影响因子：6.0 ）

ISSN： 0014-3057

年卷期： 2025 年 226 卷

页码：

收录情况： SCI

摘要： Orthopedic implants increasingly face challenges from infections caused by methicillin-resistant Staphylococcus aureus (MRSA), which forms protective biofilms that shield the bacteria from both host immune responses and conventional antibiotics. This study investigates a novel approach involving self-assembled nanoparticles composed of tea polyphenols and magnesium ions (TP-Mg or TM), which have demonstrated antibacterial and anti-inflammatory properties. While TM nanoparticles effectively inhibit MRSA biofilm formation by generating reactive oxygen species (ROS), their toxicity at high concentration pose limitations for clinical application. To address this issue, we developed a multifunctional nanoparticle solution (CSH/TM) that integrates antibacterial and immunomodulatory functions. These nanoparticles, assembled from chitosan (CS), hydroxyapatite (HA), tea polyphenols (TP), and magnesium ions (Mg), exhibit strong adhesion to 3D-printed poly(epsilon-caprolactone-L-lactide) (PCLA/20%HA, PL20H) scaffolds, effectively addressing prior challenges in incorporating bioactive agents during high-temperature printing processes. The CSH/TM-enhanced scaffolds (CSH/TM@PL20H) demonstrated a synergistic effect by releasing CS and TP to inhibit MRSA growth, promoting macrophage polarization toward the M2 phenotype, and supporting osteoblast adhesion and differentiation. This strategy represents a promising solution for managing bone defect infections by integrating antibacterial and regenerative functions into a single therapeutic platform.

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