Effects of Prevotella copri on insulin, gut microbiota and bile acids

文献类型： 外文期刊

第一作者： Gong, Jiatai

作者： Gong, Jiatai;Zhang, Qianjin;Hu, Ruizhi;Yang, Xizi;Fang, Chengkun;Yao, Liping;Lv, Jing;Wang, Long;Shi, Mingkun;Zhang, Wentao;Ma, Siqi;Xiang, Hongkun;Zhang, Hongfu;Hou, De-Xing;Yin, Yulong;He, Jianhua;Wu, Shusong;Zhang, Hongfu;Hou, De-Xing;Peng, Lijun

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关键词： Obesity; prevotella copri; insulin; gut microbiota; bile acids

期刊名称：GUT MICROBES （ 影响因子：12.2； 五年影响因子：12.4 ）

ISSN： 1949-0976

年卷期： 2024 年 16 卷 1 期

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收录情况： SCI

摘要： Obesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the underlying mechanism remains unclear. In this study, a significant positive correlation was observed between Prevotella copri (P. copri) and obesity in children (p = 0.003). Next, the effect of P. copri on obesity was explored by using fecal microbiota transplantation (FMT) experiment. Transplantation of P. copri. increased serum levels of fasting blood glucose (p < 0.01), insulin (p < 0.01) and interleukin-1 beta (IL-1 beta) (p < 0.05) in high-fat diet (HFD)-induced obese mice, but not in normal mice. Characterization of the gut microbiota indicated that P. copri reduced the relative abundance of the Akkermansia genus in mice (p < 0.01). Further analysis on bile acids (BAs) revealed that P. copri increased the primary BAs and ursodeoxycholic acid (UDCA) in HFD-induced mice (p < 0.05). This study demonstrated for the first time that P. copri has a significant positive correlation with obesity in children, and can increase fasting blood glucose and insulin levels in HFD-fed obese mice, which are related to the abundance of Akkermansia genus and bile acids.

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