Integrated metabolomic and transcriptomic analysis highlight the flavonoid response to antioxidant activity and Aspergillus flavus resistance in peanut seed coats

文献类型： 外文期刊

第一作者： Zhao, Xuejie

作者： Zhao, Xuejie;Xing, Minghui;Zhang, Lijing;Huang, Jinyong;Han, Suoyi;Zhang, Xinyou

作者机构：

关键词： Peanut; Metabolomics; Transcriptomic; Aspergillus flavus; Antioxidant activity; Flavonoid biosynthesis

期刊名称：BMC PLANT BIOLOGY （ 影响因子：4.8； 五年影响因子：5.4 ）

ISSN： 1471-2229

年卷期： 2025 年 25 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundPeanut seeds exhibit a high susceptibility to infection by Aspergillus flavus (A. flavus) post-harvest, which significantly limits their storage and marketability. The peanut seed coat acts as a crucial barrier against A. flavus, containing abundant flavonoids. Despite ongoing research, a comprehensive understanding of the inhibitory effects of flavonoids present in peanut seed coats on A. flavus remains elusive.ResultsThis study reveals significant differences in antioxidant activities and resistance to A. flavus among seed coat extracts from different peanut cultivars. A total of 1,314 metabolites were identified through untargeted metabolomics, among which flavonoids enhance both antioxidant activity and pigmentation in the seed coat. Compounds such as anthocyanins, aurones, and chalcones were strongly associated with increased resistance to A. flavus. Notably, cyanidin-3-O-sophoroside exhibited the highest concentration (10.83 mg/g dry weight) and demonstrated a minimum inhibitory concentration (MIC) of 50 mu g/mL. By integrating transcriptomic and metabolomic data, we revealed candidate genes and metabolic pathways potentially associated with anthocyanin biosynthesis.ConclusionsThis study provides novel insights into the biochemical mechanisms underlying peanut resistance to A. flavus, while also supporting the valorization of peanut by-products and the breeding of resistant cultivars.

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