DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation

文献类型： 外文期刊

第一作者： Zhang, Yanlu

作者： Zhang, Yanlu;Zhou, Baohua;Zhang, Yanlu;Zhou, Xueping;Zhou, Baohua

作者机构：

关键词： Allergic airway inflammation;Th2;TSLP

期刊名称：EUROPEAN JOURNAL OF IMMUNOLOGY （ 影响因子：5.532； 五年影响因子：5.384 ）

ISSN： 0014-2980

年卷期： 2012 年 42 卷 7 期

页码：

收录情况： SCI

摘要： Thymic stromal lymphopoietin (TSLP) plays important roles in the pathogenesis of allergic diseases. Whether and how TSLP is involved in the initial priming of T helper type-2 (Th2) differentiation against harmless antigen remains unclear. Using an intranasal sensitization protocol with OVA and LPS, we showed that TSLP signaling is required for low-dose LPS-induced Th2 inflammation, but not for high-dose LPS-induced Th1 immunity. We further demonstrated that low-dose LPS-activated bone marrow-derived dendritic cells expressed relatively high Tslp but low Il12a, and were able to prime naive DO11.10 T cells to differentiate into Th2 cells in a TSLP-dependent manner. After transfer into wild-type recipient mice, the low-dose LPS-activated OVA-loaded dendritic cells (DCs) induced airway eosinophilia, but primed neutrophil-dominated airway inflammation when TSLP-deficient DCs were used. These studies demonstrate that TSLP released by DCs in response to a low concentration of LPS plays a role in priming Th2 differentiation and thus may serve as a polarizing third signal, in addition to antigen/MHC class II and co-stimulatory factors, from antigen-presenting DCs to direct effector T-cell differentiation.

分类号： Immunology

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