An Integrated Strategy for Purification by Combining Solid-Phase Extraction with Dispersive-Solid-Phase Extraction for Detecting 22 Pesticides and Metabolite Residues in Fish

文献类型： 外文期刊

第一作者： Guo, Yage

作者： Guo, Yage;Xu, Jun;Wu, Xiaohu;Dong, Fengshou;Liu, Xingang;Zheng, Yongquan;Zhang, Jie

作者机构：

关键词： fish; pesticide residues; internal standard method; matrix effect

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2021 年 69 卷 25 期

页码：

收录情况： SCI

摘要： A robust isotope-labeled internal standard method was established for the detection of 22 pesticides and metabolite residues in four kinds of fish; two were from freshwater fish, and two were from marine fish. Pesticides with wide application possibilities in rice in China, strong leaching to water, or high bioconcentration factors (BCF) in fish were selected. The samples were extracted with 1% acetic acid-99% acetonitrile. The extracts were first purified by solid-phase extraction (PEP-plus), cleaned with dispersive-solid-phase extraction (PSA and C18), and finally analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The results showed that good linearities for the target compounds were observed in the range of 0.1-100 ng/mL, and the correlation coefficient (R-2) of each compound was greater than 0.99. The recoveries of the method were within 70-120% with RSDs <20% at three different spiked concentration levels (0.5, 5, and 100 ng/g). The quantitative limit of the method was 0.5-5-ng/g. The method is shown to be sensitive and accurate and can meet the demands for the quantitative analysis of pesticides in fish.

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