Covalent Organic Framework-Based Theranostic Platforms for Restricting H1N1 Influenza Virus Infection

文献类型： 外文期刊

第一作者： Ding, Luo-Gang

作者： Ding, Luo-Gang;Shi, Min;Li, Jian-Da;Liu, Fei;Zhang, Yu-Yu;Yu, Jiang;Wu, Jia-Qiang;Ji, Xiang;Liu, Yue-Yue

作者机构：

关键词： crystal porous materials; microenvironment-responsive; controlled release; fluorescence imaging; diagnosis and therapy

期刊名称：INTERNATIONAL JOURNAL OF NANOMEDICINE （ 影响因子：6.6； 五年影响因子：7.5 ）

ISSN： 1178-2013

年卷期： 2024 年 19 卷

页码：

收录情况： SCI

摘要： Background: Influenza A (H1N1) virus is a highly contagious respiratory disease that causes severe illness and death. Vaccines and antiviral drugs are limited by viral variation and drug resistance, so developing efficient integrated theranostic options appears significant in anti-influenza virus infection. Methods: In this study, we designed and fabricated covalent organic framework (COF) based theranostic platforms (T705@DATACOF-Pro), which was composed of an RNA polymerase inhibitor (favipiravir, T705), the carboxyl-enriched COF (DATA-COF) nanocarrier and Cy3-labeled single DNA (ssDNA) probe. Results: The multi-porosity COF core provided an excellent micro-environment and smooth delivery for T705. The ssDNA probe coating bound to the nucleic acids of H1N1 selectively, thus controlling drug release and allowing fluorescence imaging. The combination of COF and probe triggered the synergism, promoting drug further therapeutic outcomes. With the aid of T705@DATA-COF-Pro platforms, the H1N1-infected mouse models lightly achieved diagnosis and significantly prolonged survival. Conclusion: This research underscores the distinctive benefits and immense potential of COF materials in nano-preparations for virus infection, offering novel avenues for the detection and treatment of H1N1 virus infection.

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