Chitosan oligosaccharide improves intestinal homeostasis to achieve the protection for the epithelial barrier of female Drosophila melanogaster via regulating intestinal microflora

文献类型： 外文期刊

第一作者： Wang, Lu

作者： Wang, Lu;Zhang, Cheng;Fan, Shuhang;Zhou, Weihao;Zhou, Zhaohui;Liu, Yuhang;Wang, Qianna;Dai, Xianjun;Wang, Jianfeng;Liu, Wei;Dai, Xianjun

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关键词： chitosan oligosaccharide; Drosophila melanogaster; oxidant stress; intestinal homeostasis; intestinal microflora

期刊名称：MICROBIOLOGY SPECTRUM （ 影响因子：3.7； 五年影响因子：5.9 ）

ISSN： 2165-0497

年卷期： 2024 年 12 卷 4 期

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收录情况： SCI

摘要： Chitosan oligosaccharide (COS) is a new type of marine functional oligosaccharide with biological activities such as regulating intestinal microflora and improving intestinal immunity. In this study, female Drosophila melanogaster was used as a model organism to evaluate the effect of COS on intestinal injury by H2O2 induction, and its mechanism was explored through the analysis of intestinal homeostasis. The results showed that 0.25% of COS could effectively prolong the lifespan of stressed female D. melanogaster by increasing its antioxidant capacity and maintaining intestinal homeostasis, which included protecting the mechanical barrier, promoting the chemical barrier, and regulating the biological barrier by affecting its autophagy and the antioxidant signaling pathway. Additionally, the protective effect of COS on the intestinal barrier and homeostasis of D. melanogaster under oxidative stress status is directly related to its regulation of the intestinal microflora, which could decrease excessive autophagy and activate the antioxidant system to promote health.

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