Sturgeon cartilage-derived chondroitin sulfate exhibited anti-inflammatory activity against dextran sulfate sodium-induced colitis via modification of gut microbiota

文献类型： 外文期刊

第一作者： Wu, Ruiyun

作者： Wu, Ruiyun;Wang, Zhenyu;Wu, Ruiyun;Han, Zixin;Shang, Nan;Li, Pinglan

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关键词： Sturgeon cartilage; Chondroitin sulfate; Anti-inflammatory activity; Dextran sulfate sodium-induced colitis; Gut microbiota

期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：7.4； 五年影响因子：7.8 ）

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年卷期： 2025 年 14 卷 4 期

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收录情况： SCI

摘要： Chondroitin sulfate (CS) is one of the main bioactive compounds in animal cartilage. In this study, the antiinflammatory activity of sturgeon-derived chondroitin sulfate (SCS) was evaluated in the dextran sulfate sodium (DSS)-induced BALB/c mice model. Orally administration of SCS significantly alleviated the DSSinduced colitis symptoms, including the reduction of crypt depth, inhibition of the abnormal crypt foci formation, down-regulation of the proinflammatory biomarkers (NO, interleukin (IL)-6, IL-1 beta and tumor necrosis factor-alpha) and up-regulation of the anti-inflammatory biomarkers (IL-10 and IL-4). The gut microbiota analysis revealed that SCS alters the intestinal microbiota composition in colitis mice, especially the increase of the relative abundance of Ruminococcaceae and Lachnospiraceae. This alternation further induced primary bile acids convert into secondary bile acids. With SCS administration, the levels of deoxycholic acid (DCA) and litho cholic acid (LCA) were increased by 1.5-and 2.5-fold, respectively. The stimulated secretion of DCA and LCA showed further activation of the NF-kappa B signaling pathway, thereby suppressing the inflammatory response and attenuating inflammatory bowel disease (IBD) in mice. This study provided a valuable strategy for colitis prevention and treatment with sturgeon cartilage by-products. (c) 2025 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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