Hypothermia-mediated oxidative stress induces immunosuppression, morphological impairment and cell fate disorder in the intestine of freshwater drum, Aplodinotus grunniens

文献类型： 外文期刊

第一作者： Chen, Jianxiang

作者： Chen, Jianxiang;Xu, Pao;Wen, Haibo;Xue, Miaomiao;Wang, Qingyong;He, Jiyan;He, Changchang;Su, Shengyan;Li, Jianlin;Yu, Fan;Feng, Wenrong;Wang, Meiyao;Song, Changyou;Li, Hongxia;Chen, Jianxiang;Xu, Pao;Wen, Haibo;Su, Shengyan;Li, Jianlin;Yu, Fan;Feng, Wenrong;Wang, Meiyao;Song, Changyou;Li, Hongxia

作者机构：

关键词： Hypothermia; Antioxidation; Immunity; Apoptosis; Ferroptosis; Freshwater drum

期刊名称：AQUACULTURE （ 影响因子：4.5； 五年影响因子：4.6 ）

ISSN： 0044-8486

年卷期： 2023 年 575 卷

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收录情况： SCI

摘要： The mechanism of the intestine in freshwater drum response to hypothermia exposure has not been investigated, despite the fact that it is a key organ of metabolism and immunity. Here, we conducted an 8-day hypothermia experiment under 10 degrees C to uncover the underlying mechanism in the intestine of freshwater drum. Morphologically, hypothermia exposure caused intestinal microvilli shortening, mitochondrial structure disruption, and tight junction damage. Physiologically, immunosuppression and inflammatory response were involved in the intestinal hypothermia response. According to transcriptome analysis, we discovered that hypothermia exposure induced apoptosis and ferroptosis in the intestine. Combined with correlation analyses, oxidative stress was considered critical in modifying the intestinal hypothermia response. In conclusion, hypothermia-induced oxidative stress leads to intestinal structure damage, immunosuppression and cell fate alterations, ultimately affecting the well-being of freshwater drum. This may provide some insights into hypothermia prevention in aquaculture management.

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