Polymorphisms in BMPRIB gene affect litter size in Chinese indigenous sheep breed

文献类型： 外文期刊

第一作者： Mo, Futao

作者： Mo, Futao;Sun, Weibo;Zhang, Liping;Zhang, Xiaoyan;Xiao, Fan;Jin, Jipeng;Mo, Futao;La, Yongfu;Jia, Jianlei

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关键词： BMPRIB; litter size; sheep; SNPs; allele distribution

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.271； 五年影响因子：1.697 ）

ISSN： 1049-5398

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收录情况： SCI

摘要： The BMPRIB gene belongs to the TGF-beta superfamily and is considered to be a regulator of sheep reproductive performance. Single nucleotide polymorphisms (SNPs) of BMPRIB gene in the Small Tail Han, Hu, Mongolian, Oula, Gansu Alpine Fine-wool, Dorper and Australian White sheep were detected by Sanger sequencing. Five SNPs (rs427897187 G > A, rs418841713 A > G, rs159952533 T > C, rs429416173 C > A and rs403555643 A > G) of BMPRIB gene were identified. For rs427897187 G > A, further analysis revealed that genotype GG and GA had 0.26 (p < 0.05) and 0.33 (p < 0.05) litter size less than those with genotype AA in Oula sheep. For rs403555643 A > G, further analysis revealed that genotype GG and AG had 0.65 (p < 0.05) and 0.38 (p < 0.05) litter size more than those with genotype AA in Oula sheep, and genotype GG had 0.56 (p < 0.05) litter size more than those with genotype AA in Mongolian sheep. The results showed that rs427897187 G > A and rs403555643 A > G are potential molecular markers wich could improve litter size of Chinese indigenous sheep and be used in Chinese indigenous sheep breeding.

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