A single point mutation causes one-way alteration of pheromone receptor function in two Heliothis species

文献类型： 外文期刊

第一作者： Cao, Song

作者： Cao, Song;Liu, Yang;Wang, Bing;Wang, Guirong;Cao, Song;Wang, Guirong

作者机构：

期刊名称：ISCIENCE （ 影响因子：5.458； 五年影响因子：5.458 ）

ISSN：

年卷期： 2021 年 24 卷 9 期

页码：

收录情况： SCI

摘要： The sex pheromone processing system of moths has been a major focus of research on olfaction and speciation, as it is highly specific and closely related to reproductive isolation. The two noctuid moths Heliothis virescens and Heliothis subflexa have been used as a model for deciphering the mechanisms underlying differentiation in pheromone communication, but no information exist regarding the functions of the pheromone receptors (PRs) of H. subflexa. Here, we functionally characterized all candidate PRs of H. subflexa, and found that only the response profile of OR6 differed between the two species. Through domain swapping and site-directedmutation followed by functional characterization, we identified a critical amino acid in OR6 caused a one-way alteration in specificity. This result suggests HsubOR6 evolved from an ancestral OR6 gene with a HvirOR6-like function and implies that the evolutionary direction of the receptor specificity was from the H. virescens-like pattern to H. subflexa-like pattern.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序