Anti-tumor activity and the mechanism of SIP-S: A sulfated polysaccharide with anti-metastatic effect

文献类型： 外文期刊

第一作者： Zong, Aizhen

作者： Zong, Aizhen;Zhang, Yan;Song, Xinlei;Liu, Chunhui;Jiang, Wenjie;Wang, Fengshan;Liu, Yuhong;Shi, Yikang;Cao, Hongzhi;Liu, Chunhui;Wang, Fengshan;Cheng, Yanna;Zong, Aizhen;Du, Fangling

作者机构：

关键词： SIP-S; Cyclophosphamide; Anti-tumor activity; Immunoenhancing activity; Apoptosis

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN： 0144-8617

年卷期： 2015 年 129 卷

页码：

收录情况： SCI

摘要： Our previous studies demonstrated that SIP-S had anti-metastatic activity and inhibited the growth of metastatic foci. Here we report the anti-tumor and immunoregulatory potential of SIP-S. SIP-S could significantly inhibit tumor growth in S180-bearing mice, and the inhibition rates was 43.7% at 30 mg/kg d. Besides, SIP-S could improve the thymus and spleen indices of S180-bearing mice and the mice treated with CTX. The combination of SIP-S (15 mg/kg d) with CTX (12.5 mg/kg d) showed higher anti-tumor potency than CTX (25 mg/kg d) alone. These results indicated that SIP-S had immunoenhancing and anticancer activity, and the immunoenhancing activity might be one mechanism for its anti-tumor activity. Flow cytometry results showed that SIP-S could induce tumor cells apoptosis. Western blot analysis indicated that SIP-S could upregulate the expression of pro-apoptotic proteins, caspase-3, -8, -9 and Bax, and downregulate the expression of anti-apoptotic protein PARP-1 in tumor cells in a dose-dependent manner. In summary, SIP-S has anti-tumor activity, which may be associated with its immunostimulating and pro-apoptotic activity. (C) 2015 Elsevier Ltd. All rights reserved.

分类号： O629`Q53

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