The multifunctional roles of autophagy in the innate immune response: Implications for regulation of transplantation rejection

文献类型： 外文期刊

第一作者： Zhang, Kunli

作者： Zhang, Kunli;Zhang, Jianfeng;Li, Chunling;Zhai, Shaolun;Xu, Zhihong;Huang, Qiuyan;Wang, Sutian;Peng, Laru;Lin, Sen;Liu, Jie;Zhang, Jianfeng;Wang, Sutian

作者机构：

关键词： organ transplantation; graft rejection; autophagy; innate immune response; oxidative stress; cell death

期刊名称：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY （ 影响因子：5.5； 五年影响因子：5.8 ）

ISSN： 2296-634X

年卷期： 2022 年 10 卷

页码：

收录情况： SCI

摘要： Organ transplantation is the main treatment for end-stage organ failure, which has rescued tens of thousands of lives. Immune rejection is the main factor affecting the survival of transplanted organs. How to suppress immune rejection is an important goal of transplantation research. A graft first triggers innate immune responses, leading to graft inflammation, tissue injury and cell death, followed by adaptive immune activation. At present, the importance of innate immunity in graft rejection is poorly understood. Autophagy, an evolutionarily conserved intracellular degradation system, is proven to be involved in regulating innate immune response following graft transplants. Moreover, there is evidence indicating that autophagy can regulate graft dysfunction. Although the specific mechanism by which autophagy affects graft rejection remains unclear, autophagy is involved in innate immune signal transduction, inflammatory response, and various forms of cell death after organ transplantation. This review summarizes how autophagy regulates these processes and proposes potential targets for alleviating immune rejection.

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