Recent Advances in Deciphering the Mechanisms and Biological Functions of DNA Demethylation

文献类型： 外文期刊

第一作者： Feng, Yang

作者： Feng, Yang;Chen, Sheng-Jun;Feng, Yang;Yuan, Bi-Feng

作者机构：

关键词： Epigenetics; DNA; DNA methylation; 5-Methylcytosine; Demethylation; Mechanisms; Biological functions; C-C bond cleavage; Mass spectrometry

期刊名称：CHINESE JOURNAL OF CHEMISTRY （ 影响因子：5.4； 五年影响因子：4.4 ）

ISSN： 1001-604X

年卷期： 2023 年

页码：

收录情况： SCI

摘要： 5-Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic DNA of higher eukaryotes. It has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation (TET)-mediated oxidation of 5mC followed by thymine DNA glycosylase (TDG)-initiated base excision repair (BER). Recent findings also have identified an alternative pathway of DNA demethylation. In this pathway, TET enzymes directly oxidize 5mC to form 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC). These modified bases can undergo direct deformylation or decarboxylation, respectively. Additionally, DNA demethylation can also occur through the deamination of 5mC and 5hmC, resulting in the production of thymine and 5-hydroxymethyluracil (5hmU), respectively. Various DNA demethylation pathways possess critical functional implications and roles in biological processes. This Recent Advances article will focus on the studies of mechanisms and biological functions of DNA demethylation, shedding light on the reversible nature of the epigenetic modification of 5mC.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序