A Novel Polysaccharide From Heimioporus retisporus Displays Hypoglycemic Activity in a Diabetic Mouse Model

文献类型： 外文期刊

第一作者： Feng, Xiaobin

作者： Feng, Xiaobin;Wang, Peng;Liu, Qinghong;Lu, Yuxiao;Zhang, Zejun;Yao, Chunxin;Tian, Guoting

作者机构：

关键词： Heimioporus retisporus; polysaccharide; characterization; hypoglycemia; cardioprotective

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）

ISSN： 2296-861X

年卷期： 2022 年 9 卷

页码：

收录情况： SCI

摘要： A novel polysaccharide, Heimioporus retisporus Polysaccharide (HRP) was extracted from the edible mushroom Heimioporus retisporus. HRP had weight-average molecular weight 1,949 kDa and number-average molecular weight 873 kDa, and its major components were arabinose (0.71%), galactose (12.93%), glucose (49.00%), xylose (8.59%), mannose (17.78%), and glucuronic acid (10.99%). Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy revealed that HRP was composed of 1,3-linked beta-D-glucose, 1,6-linked beta-D-mannose, 1,6-linked beta-D-galactose, 1,4-linked beta-D-galactose, 1,4-linked beta-D-xylose, and 1,5-linked alpha-L-arabinose. Thermogravimetric analysis indicated that degradation temperature (T-0) of HRP was 200 degrees C. In an STZ-induced diabetic mouse model, oral administration of HRP (40 mg/kg/d) for 28 days significantly reduced blood glucose levels, and reduced heart organ index by decreasing expression of IL-6 and TNF-alpha. Our findings indicate hypoglycemic effect of HRP, and its potential application as a hypoglycemic agent.

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