Central nervous system disturbances by thiamethoxam in Japanese quail ( Coturnix japonica): In vivo, ex vivo, and in silico study

文献类型： 外文期刊

第一作者： Pan, Yifan

作者： Pan, Yifan;Niu, Yue;Fu, Yongqi;Wang, Shuaimeng;Pan, Yifan;Niu, Yue;Fu, Yongqi;Wang, Shuaimeng;Chang, Jing;Liu, Wentao;Hao, Weiyu;Xu, Peng;Yang, Lu

作者机构：

关键词： Nicotinic acetylcholine receptors (nAChRs); Birds; Neurotoxicity; Neonicotinoids; Clothianidin

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：7.3； 五年影响因子：8.1 ）

ISSN： 0269-7491

年卷期： 2024 年 360 卷

页码：

收录情况： SCI

摘要： The neurotoxic effects of neonicotinoids (NEOs) have been widely reported in relation to the poisoning of wild birds, yet the underlying molecular mechanism has remained elusive. This study employed Japanese quails (Coturnix japonica) and primary quail embryonic neurons as in vivo and ex vivo models, respectively, to investigate the neurotoxic effects and mechanism of thiamethoxam (TMX), a representative neonicotinoid insecticide, at environmentally relevant concentrations. Following a 28-day exposure to TMX, metabolomic analysis of quail brain revealed TMX-induced changes in glutamatergic, GABA-ergic, and dopaminergic function. Subsequent ex vivo and in silico experimentation revealed that the activation of nicotinic acetylcholine receptors and calcium signaling, induced by clothianidin (CLO), the primary metabolite of TMX, served as upstream events for the alterations in neurotransmitter synthesis, metabolism, release, and uptake. Our findings propose that the disruption of the central nervous system, caused by environmentally significant concentrations of NEOs, may account for the avian poisoning events induced by NEOs.

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