Organized assembly of chitosan into mechanically strong bio-composite by introducing a recombinant insect structural protein OfCPH-1

文献类型： 外文期刊

第一作者： Chen, Lei

作者： Chen, Lei;Wang, Guirong;Yang, Qing;Chen, Lei;Wang, Guirong;Yang, Qing;Shao, Fei;Chen, Kaiwen;Wu, Nan;Sun, Bingbing;Ge, Dan;Wang, Huanan;Yang, Qing;Shao, Fei;Chen, Kaiwen;Wu, Nan;Sun, Bingbing;Ge, Dan;Wang, Huanan;Yang, Qing

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关键词： Bio-composite; Chitosan; Insect cuticle protein; Hydrated chitosan crystal

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：11.2； 五年影响因子：10.2 ）

ISSN： 0144-8617

年卷期： 2024 年 334 卷

页码：

收录情况： SCI

摘要： Chitosan, known for its appealing biological properties in packaging and biomedical applications, faces challenges in achieving a well -organized crystalline structure for mechanical excellence under mild conditions. Herein, we propose a facile and mild bioengineering approach to induce organized assembly of amorphous chitosan into mechanically strong bio-composite via incorporating a genetically engineered insect structural protein, the cuticular protein hypothetical -1 from the Ostrinia furnacalis (OfCPH-1). OfCPH-1 exhibits high binding affinity to chitosan via hydrogen -bonding interactions. Simply mixing a small proportion (0.5 w/w%) of bioengineered OfCPH-1 protein with acidic chitosan precursor induces the amorphous chitosan chains to form fibrous networks with hydrated chitosan crystals, accompanied with a solution -to -gel transition. We deduce that the water shell destruction driven by strong protein-chitosan interactions, triggers the formation of wellorganized crystalline chitosan, which therefore offers the chitosan with significantly enhanced swelling resistance, and strength and modulus that outperforms that of most reported chitosan-based materials as well as petroleum -based plastics. Moreover, the composite exhibits a stretch -strengthening behavior similar to the training living muscles on cyclic load. Our work provides a route for harnessing the OfCPH-1-chitosan interaction in order to form a high-performance, sustainably sourced bio-composite.

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