Isolation, Identification, and Characterisation of a Novel ST2378 Aeromonas hydrophila Strain from Naturally Diseased Frogs, Rana dybowskii

文献类型： 外文期刊

第一作者： Zhao, Ran

作者： Zhao, Ran;Wang, Jing;Wang, Di;Wang, Yanan;Hu, Guo;Li, Shaowu

作者机构：

关键词： Aeromonas hydrophila; Rana dybowskii; virulence genotype; antimicrobial susceptibility; MLST

期刊名称：PATHOGENS （ 影响因子：3.3； 五年影响因子：3.5 ）

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年卷期： 2024 年 13 卷 7 期

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收录情况： SCI

摘要： In 2023, Rana dybowskii exhibiting characteristic skin ulcers were found on a farm in northeastern China. Subsequently, two dominant bacteria, Aeromonas hydrophila Rd001 and Acinetobacter johnsonii Rd002, were isolated from naturally infected R. dybowskii. Experimental infection confirmed that Rd001 was the primary pathogen responsible for the disease in R. dybowskii, with a mean lethal dose (LD50) of 6.25 x 10(2) CFU/g. The virulence genotype of Rd001 was identified as ser+/aha+/lip+/nuc+/hlyA+/aer+/alt+/ast+/act+. Antimicrobial susceptibility testing indicated that Rd001 was sensitive to enrofloxacin, flumequine, and neomycin. MLST analysis showed that Rd001 belonged to a new sequence type of A. hydrophila, named ST2378. This study offered the first comprehensive investigation into the pathogenicity, virulence genotypes, antimicrobial resistance, and genetic traits of A. hydrophila isolated from R. dybowskii, providing a theoretical foundation for preventing and controlling A. hydrophila infections.

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