Modularized viromimetic polymer nanoparticle vaccines (VPNVaxs) to elicit durable and effective humoral immune responses

文献类型： 外文期刊

第一作者： Huang, Zichao

作者： Huang, Zichao;Liu, Liping;Zhao, Jiayu;Ma, Sheng;Si, Xinghui;Zhu, Zhenyi;Song, Wantong;Chen, Xuesi;Huang, Zichao;Liu, Liping;Zhao, Jiayu;Zhu, Zhenyi;Song, Wantong;Chen, Xuesi;Zhuang, Xinyu;Jin, Ningyi;Tian, Mingyao;Ma, Sheng;Si, Xinghui;Song, Wantong;Chen, Xuesi;Wu, Fan

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关键词： vaccine; polymer; nanomaterials; SARS-CoV-2

期刊名称：NATIONAL SCIENCE REVIEW （ 影响因子：20.6； 五年影响因子：22.3 ）

ISSN： 2095-5138

年卷期： 2024 年 11 卷 3 期

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收录情况： SCI

摘要： Virus-like particle (VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However, the time-consuming and complicated processes in establishing a current recombinant-protein-based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine (VPNVax), with subunit receptor-binding domain (RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid (PEG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%-25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics. A polymeric nanoparticle-based two-step strategy was reported to rapidly construct viromimetic vaccines against SARS-CoV-2 or other pandemics.

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