Recent advance of lipid droplets fluorescence imaging with aggregation-induced emission luminogens (AIEgens)

文献类型： 外文期刊

第一作者： Wang, Lingyun

作者： Wang, Lingyun;Chen, Xiaoli;Tang, Hao;Cao, Derong;Ran, Xueguang

作者机构：

关键词： Lipid droplets (LDs); Aggregation-induced emission luminogens; (AIEgens); Fluorescence bioimaging; Design

期刊名称：DYES AND PIGMENTS （ 影响因子：5.122； 五年影响因子：4.36 ）

ISSN： 0143-7208

年卷期： 2022 年 203 卷

页码：

收录情况： SCI

摘要： As reservoirs of neutral lipids for energy storage to drive energy-demanding processes, lipid droplets (LDs) play an important role in regulating numerous cellular functions. In addition, LDs are crucial in the progression of some diseases, such as cancer, atherosclerosis, fatty liver disease, hyperlipidemia, diabetes, and neurodegeneration. In clinical diagnosis and biomedical research, fluorescence bioimaging of LDs for the dynamic localization and real-time analysis is commonly utilized. The aggregation-induced emission luminogens (AIEgens) are promising candidates for LD imaging owing to their high signal-to-noise (S/N) ratio, "lit up" character, excellent photostability, and good biocompatibility. In this review, the design principles and various kinds of AIEgens (reactive AIEgens, red/NIR emission AIEgens, two-photon AIEgens, AIE + ESIPT based luminogens, organoboron materials and other AIEgens) for LDs imaging, LDs dynamic detection, and imaging of other lipidrich organisms are summarized. We anticipate that this review can stimulate further expanding more AIEgens for LDs imaging and detection.

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