The role of lignin in 17β-estradiol biodegradation: insights from cellular characteristics and lipidomics

文献类型： 外文期刊

第一作者： Pan, Hanyu

作者： Pan, Hanyu;Hao, Peng;Li, Qiannan;Lv, Zongshuo;Gao, Kun;Yang, Lianyu;Gao, Yunhang;Liang, Xiaojun

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关键词： 17 beta-estradiol; Lignin; Biodegradation; Cells characteristics; Lipidomics; Mechanisms of lipid action

期刊名称：MICROBIAL CELL FACTORIES （ 影响因子：4.9； 五年影响因子：6.1 ）

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年卷期： 2024 年 23 卷 1 期

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收录情况： SCI

摘要： 17 beta-estradiol (E2) is an endocrine disruptor, and even trace concentrations (ng/L) of environmental estrogen can interfere with the endocrine system of organisms. Lignin holds promise in enhancing the microbial degradation E2. However, the mechanisms by which lignin facilitates this process remain unclear, which is crucial for understanding complex environmental biodegradation in nature. In this study, we conducted a comprehensive analysis using cellular and lipidomics approaches to investigate the relationship between E2-degrading strain, Rhodococcus sp. RCBS9, and lignin. Our findings demonstrate that lignin significantly enhances E2 degradation efficiency, reaching 94.28% within 5 days with the addition of 0.25 mM lignin. This enhancement is associated with increased microbial growth and activity, reduced of membrane damages, and alleviation of oxidative stress. Fourier Transform Infrared Spectroscopy (FTIR) results indicate that lignin addition alters lipid peaks. Consequently, by analyzing lipid metabolism changes, we further elucidate how lignin addition promotes E2 degradation.

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