Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases

文献类型： 外文期刊

第一作者： Zhao, Tong

作者： Zhao, Tong;Zhu, Yuchen;Zhao, Rui;Xiong, Shiyi;Sun, Jing;Zhang, Juntao;Yang, Haixia;Deng, Jianjun;Fan, Daidi;Deng, Jianjun

作者机构：

关键词： Nuciferine; Inflammation; Structure-activity relationships; Bioactivities; Mechanisms

期刊名称：PHARMACOLOGICAL RESEARCH （ 影响因子：9.3； 五年影响因子：8.8 ）

ISSN： 1043-6618

年卷期： 2023 年 193 卷

页码：

收录情况： SCI

摘要： Nuciferine aporphine alkaloid mainly exists in Nelumbo nucifera Gaertn and is a beneficial to human health, such as anti-obesity, lowering blood lipid, prevention of diabetes and cancer, closely associated with inflammation. Importantly, nuciferine may contribute to its bioactivities by exerting intense anti-inflammatory activities in multiple models. However, no review has summarized the anti-inflammatory effect of nuciferine. This review critically summarized the information regarding the structure-activity relationships of dietary nuciferine. Moreover, biological activities and clinical application on inflammation-related diseases, such as obesity, diabetes, liver, cardiovascular diseases, and cancer, as well as their potential mechanisms, involving oxidative stress, metabolic signaling, and gut microbiota has been reviewed. The current work provides a better understanding of the anti-inflammation properties of nuciferine against multiple diseases, thereby improving the utilization and application of nuciferine-containing plants across functional food and medicine.

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