Antifungal activities of metconazole against the emerging wheat pathogen Fusarium pseudograminearum

文献类型： 外文期刊

第一作者： Liu, Xin

作者： Liu, Xin;Wang, Shuang;Wang, Liwen;Shi, Jianrong;Xu, Jianhong;Liu, Xin;Wang, Shuang;Wang, Liwen;He, Dan;Shi, Jianrong;Gao, Tao;Xu, Jianhong;Wu, Jiawen;Fan, Zhongyue;Mohamed, Sherif Ramzy;Dawood, Dawood H.

作者机构：

关键词： Fusarium pseudograminearum; Metconazole; Fusarium crown rot; Sensitivity; RNA-Seq; Control efficacy

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.966； 五年影响因子：4.591 ）

ISSN： 0048-3575

年卷期： 2023 年 190 卷

页码：

收录情况： SCI

摘要： Fusarium crown rot of wheat is a serious fungal disease that occurs worldwide. The disease has been emerging in the major wheat-growing areas in China since 2010. Fusarium pseudogramineaum is the predominant causative pathogen of crown rot of wheat in China. The 14 alpha-demethylation inhibitor (DMI) fungicide metconazole has been shown to be effective against Fusarium spp., but little is known about its specific activity against F. pseudogramineaum. Metconazole exhibited strong antifungal activities against all thirty-nine F. pseudogramineaum strains collected from the major wheat-growing areas in China. Metconazole inhibited mycelial growth and conidial germ tube elongation of F. pseudograminearum. Metconazole treatment significantly reduced the production of major toxins and the expression levels of toxin biosynthesis genes. Genome-wide transcriptional profiling of F. pseudograminearum in response to metconazole indicated that the expression of genes involved in ergosterol biosynthesis, including fungicide target genes (cyp51 genes), was significantly induced by metconazole. Nine ATP-binding cassette (ABC) transporter-encoding genes were significantly expressed in response to metconazole treatment. Reduced ergosterol production and antioxidant enzyme ac-tivities were observed after metconazole treatment. Greenhouse experiments indicated a significant reduction in crown rot occurrence in wheat after seed treatment with metconazole. This study evaluated the potential of metconazole to manage wheat crown rot and provides information to understand its antifungal activities and mechanism of action against F. pseudograminearum.

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