Base-Catalyzed Cascade Cyclization of Acyl Cyanides and Isocyanates for the Synthesis of Oxazoles
文献类型： 外文期刊
第一作者： Zhang, Wei
作者： Zhang, Wei;Li, Hongjun;Hou, Jing;Wan, Yaya;Zhou, Pengjuan;Tang, Dong
作者机构：
关键词： Acyl cyanides; Base-promoted; Cyclization reaction; Oxazoles; Isocyanates
期刊名称：CHEMISTRYSELECT （ 影响因子：2.0； 五年影响因子：2.0 ）
ISSN： 2365-6549
年卷期： 2025 年 10 卷 4 期
页码：
收录情况： SCI
摘要： Oxazoles are key heterocyclic motifs in pharmaceuticals and natural products. We report a base-promoted method for the synthesis of oxazoles from acyl cyanides and isocyanates under mild conditions. Using KOH as a catalyst in acetonitrile at 80 degrees C, a variety of acyl cyanides with different substituents were cyclized efficiently, yielding oxazoles in good to excellent yields (up to 98%). A plausible mechanism involving 1,1-addition, 1,3-H shift, and intramolecular cyclization is proposed. This work offers a straightforward and versatile approach to oxazole synthesis.
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