TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro

文献类型： 外文期刊

第一作者： Yin, Juanbin

作者： Yin, Juanbin;Wang, Shasha;Ren, Shanhui;Liang, Zhengji;Sun, Yuefeng;Yin, Xiangping;Wang, Xiangwei;Yin, Juanbin;Ge, Junwei

作者机构：

关键词： histone deacetylase inhibitor; TMP269; rabies virus (RABV); antiviral; autophagy

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

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年卷期： 2023 年 14 卷

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收录情况： SCI

摘要： TMP269, a small molecular inhibitor of IIa histone deacetylase, plays a vital role in cancer therapeutic. However, the effect of TMP269 on the regulation of viral replication has not been studied. In the present study, we found that TMP269 treatment significantly inhibited RABV replication at concentrations without significant cytotoxicity in a dose-dependent manner. In addition, TMP269 can reduce the viral titers and protein levels of RABV at an early stage in the viral life cycle. RNA sequencing data revealed that immune-related pathways and autophagy-related genes were significantly downregulated after RABV infection treated with TMP269. Further exploration shows that autophagy enhances RABV replication in HEK-293T cells, while TMP269 can inhibit autophagy to decrease RABV replication. Together, these results provide a novel treatment strategy for rabies.

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