The toxic effect of lead exposure on the physiological homeostasis of grouper: Insight from gut-liver axis

文献类型： 外文期刊

第一作者： Duan, Yafei

作者： Duan, Yafei;Yang, Yukai;Zhang, Zhe;Nan, Yuxiu;Xiao, Meng;Yang, Yukai;Duan, Yafei

作者机构：

关键词： Grouper; Heavy metal; Gut-liver axis; Intestinal microbiota; Metabolite

期刊名称：MARINE POLLUTION BULLETIN （ 影响因子：4.9； 五年影响因子：5.6 ）

ISSN： 0025-326X

年卷期： 2024 年 207 卷

页码：

收录情况： SCI

摘要： The heavy metal lead (Pb) pollution in marine environment has been widely concerned. The liver and intestine are important for the health of fish. In this study, the grouper were exposed to 1 mu g/L Pb for 14 days, and the physiological homeostasis changes were explored via gut-liver axis. The results showed that Pb stress caused liver morphological changes, oxidative stress, and the accumulation and peroxidation of the lipids. The liver metabolism were disturbed, especially amino acid metabolism and the synthesis and degradation of ketone bodies. Pb stress also caused intestinal mucosal ablation, tight junction dysfunction and inflammatory response. Additionally, intestinal microbial diversity was decreased, and the community composition was altered especially several bacteria genera ( Ruminococcus UCG-005, Ruminococcus UCG-014, Oscillibacter, and Streptococcus) ) were significantly correlated with the physiological indexes and metabolites of the liver. These results reveal that Pb stress negatively affect the physiological homeostasis of the grouper via gut-liver axis.

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