A novel injectable sericin hydrogel with strong fluorescence for tracing

文献类型： 外文期刊

第一作者： Zhang, Yeshun

作者： Zhang, Yeshun;Cao, Xinyu;Zhang, Guozheng;Zhu, Mingkun;Yan, Hui;Li, Yurong;Zhang, Yeshun;Zhang, Guozheng;Zhu, Mingkun;Yan, Hui;Li, Yurong;Zhang, Yeshun;Zhang, Jingya

作者机构：

关键词： Sericin; Hydrogel; Self-luminescence; Double crosslinking

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2024 年 258 卷

页码：

收录情况： SCI

摘要： Hydrogel systems with strong fluorescence, as convenient tracers or bio-probes, have attracted much attention in biomedical engineering. Currently, most hydrogels endowed fluorescent properties due to modifying additional fluorophores. However, these fluorophores owing to photobleaching and toxicity limit the practical applications of hydrogels. Herein, we prepared a novel self-luminescence hydrogel through double crosslinking glutaraldehyde and hydrogen peroxide/horseradish peroxidase (H2O2/HRP) with sericin protein. The double cross-linked sericin hydrogel exhibits strong green and red intrinsic fluorescence which can be excited over a wide range of wavelengths. Moreover, this hydrogel with strong intrinsic fluorescence could penetrate thick pigskin tissue, which has potential application in implantable bio-tracer areas. In addition to the above unique properties, this sericin hydrogel possesses two types of micropore structures with high porosity, swelling properties, pH-responsive degradability, super elasticity, injectability, viscosity, and excellent biocompatibility. The investigation could significantly expand the scope of protein hydrogels in biomedical applications.

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