Chiral beta-arylalkyl-1H-1,2,4-triazoles as demethylase inhibitors: Biological evaluation and its stereoselective interaction with sterol 14 alpha-demethylase from Penicillium digitatum

文献类型： 外文期刊

第一作者： Cao, Xiufang

作者： Cao, Xiufang;Chen, Changshui;Ke, Shaoyong

作者机构：

关键词： demethylase: 9012-67-3;EC 1.5.3.2;14-alpha-demethylase: 60063-87-8;CYP51 protein;beta-laryla1kyl-1H-1;2;4-triazoles derivative;molecular docking;antifungal activity;binding activity;stereoselective interaction;R-enantiomer;S-enantiomer;chiral azole

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：3.963； 五年影响因子：4.454 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A series of chiral beta-arylalkyl-1H-1,2,4-triazole derivatives were prepared and both their in vitro antifungal activities against Penicillium digitatum and binding activity toward CYP51 protein of P. digitatum (PdCYP51) were tested. In general, the in vitro inhibitory activities of R- and S-enantiomers were in good agreement with the corresponding binding activities in cultured cells. Furthermore, the preliminary molecular docking modeling of representative compounds are described to provide more insight into their stereoselective interaction, as well as further rationalize the observations of the activities of chiral azoles as demethylase inhibitors for defense against postharvest pathogens

分类号： S4

  • 相关文献

[1]Synthesis of Novel (E)-alpha-(methoxyimino) Benzeneacetate Derivatives and their Fungicidal Activities. Wang, Xianyou,Chen, Peiyun,Pang, Yanping,Zhao, Zhilei,Wu, Guangchen,Wang, Hua.

[2]Synthesis and antifungal activity of 5-iodo-1,4-disubstituted-1,2,3-triazole derivatives as pyruvate dehydrogenase complex E1 inhibitors. He, Jun-Bo,He, Hai-Feng,Zhao, Lu,Zhang, Li,You, Ge-Yun,Feng, Ling-Ling,Wan, Jian,He, Hong-Wu,He, Jun-Bo,He, Jun-Bo.

[3]Identification of Tartary Buckwheat Tea Aroma Compounds with Gas Chromatography-Mass Spectrometry. Qin, Peiyou,Wu, Li,Ren, Guixing,Ma, Tingjun,Shan, Fang.

[4]Transport via xylem of atrazine, 2,4-dinitrotoluene, and 1,2,3-trichlorobenzene in tomato and wheat seedlings. Su, Yu H.,Liang, Yong C.,Liang, Yong C..

[5]Expression and characterization of a recombinant 2,3-dihydroxybiphenyl-1,2-dioxygenase from Pseudomonas. Xiong, Fei,Shuai, Jian-Jun,Sun, Jing,Xiong, Ai-Sheng,Shuai, Jian-Jun,Jin, Xiao-Fen,Sun, Jing,Peng, Ri-He,Yao, Quan-Hong,Zhang, Jian.

[6]A novel thermal iniferter for radical polymerization. Chen, XP,Qiu, KY,Swift, G,Westmoreland, DG,Wu, SQ.

[7]Test of hirudin activity by tracking the binding of hirudin to thrombin in the presence of BS3 cross-linking. Liu, Yanfang,Wang, Jiangmin,Huang, Qingmei,Yang, Xiaohong,Zhang, Jianhua,Yang, Jian. 2015

[8]Immunolocation and enzyme activity analysis of Cryptosporidium parvum enolase. Mi, Rongsheng,Chen, Zhaoguo,Mi, Rongsheng,Yang, Xiaojiao,Huang, Yan,Cheng, Long,Lu, Ke,Han, Xiangan,Chen, Zhaoguo,Mi, Rongsheng,Yang, Xiaojiao,Huang, Yan,Cheng, Long,Lu, Ke,Han, Xiangan,Chen, Zhaoguo. 2017

[9]SpALF4: A newly identified anti-lipopolysaccharide factor from the mud crab Scylla paramamosain with broad spectrum antimicrobial activity. Zhu, Lei,Huang, Yan-Qing,Zhou, Jun-Fang,Fang, Wen-Hong,Yao, Xiao-Juan,Wang, Hao,Li, Xin-Cang,Zhu, Lei,Huang, Yan-Qing,Zhou, Jun-Fang,Fang, Wen-Hong,Yao, Xiao-Juan,Wang, Hao,Li, Xin-Cang,Lan, Jiang-Feng,Zhang, Chao. 2014

[10]CkDREB gene in Caragana korshinskii is involved in the regulation of stress response to multiple abiotic stresses as an AP2/EREBP transcription factor. Wang, Xuemin,Chen, Xiaofang,Gao, Hongwen,Wang, Zan,Sun, Guizhi,Liu, Yun.

[11]Newly identified invertebrate-type lysozyme (Splys-i) in mud crab (Scylla paramamosain) exhibiting muramidase-deficient antimicrobial activity. Zhou, Jian,Zhao, Shu,Fang, Wen-Hong,Zhou, Jun-Fang,Zhang, Jing-Xiao,Li, Xin-Cang,Zhou, Jian,Zhao, Shu,Fang, Wen-Hong,Zhou, Jun-Fang,Zhang, Jing-Xiao,Li, Xin-Cang,Zhou, Jian,Ma, Hongyu,Lan, Jiang-Feng. 2017

[12]A novel myeloid differentiation factor 88 homolog, SpMyD88, exhibiting SpToll-binding activity in the mud crab Scylla paramamosain. Li, Xin-Cang,Zhu, Lei,Li, Lin-Gui,Huang, Yan-Qing,Lu, Jian-Xue,Fang, Wen-Hong,Kang, Wei,Ren, Qian,Ren, Qian.

[13]Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation. Zhang Xuan,Yang Liu-Meng,Chen Huan,Zheng Yong-Tang,Huang Sheng-Zhuo,Zhao You-Xing,Zhang Xuan,Zhang Xuan,Gu Wan-Gang,Wan David Chi-Cheong,Zheng Chang-Bo. 2014

[14]Specific involvement of two amino acid residues in cis-nerolidol binding to odorant-binding protein 5 AlinOBP5 in the alfalfa plant bug, Adelphocoris lineolatus (Goeze). Gu, S. -H.,Guo, Y. -Y.,Zhang, Y. -J.,Han, L.,Zhou, J. -J.. 2013

[15]Binding interactions of halogenated bisphenol A with mouse PPAR alpha: In vitro investigation and molecular dynamics simulation. Zhang, Jie,Li, Tiezhu,Wang, Tuoyi,Li, Zhuolin,Wang, Yongzhi,Wang, Yongjun,Guan, Tianzhu,Zhang, Tiehua,Yu, Hansong. 2018

[16]Design, synthesis and biological evaluation of organophosphorous-homodimers as dual binding site acetylcholinesterase inhibitors. Xie, Ruliang,Zhao, Qianfei,Zhang, Tao,Mei, Xiangdong,Ning, Jun,Fang, Jing,Tang, Yun.

[17]Investigation of the binding sites and orientation of caffeine on human serum albumin by surface-enhanced Raman scattering and molecular docking. Wang, Weinan,Duan, Yaokai,Jiang, Yong,Zhang, Liangren,Tu, Pengfei,Zhang, Wei,Zhao, Bing.

[18]Identification of borrelidin binding site on threonyl-tRNA synthetase. Zhang, Ji,Liu, Chongxi,Fang, Baozhu,Wang, Xiangjing,Xiang, Wensheng,Xiang, Wensheng.

[19]Functional and binding characterization of a single chain Fv antibody to abscisic acid and conjugated abscisic acid. Chen, Xiaojiao,Tan, Guiyu,Liu, Wei,Wang, Baomin,Zhang, Mingcai,Li, Zhaohu,Lu, Yao,Cao, Zhen.

[20]Functional analysis of female-biased odorant binding protein 6 for volatile and nonvolatile host compounds in Adelphocoris lineolatus (Goeze). Sun, L.,Wang, Q.,Wang, Q.,Khashaveh, A.,Zhang, Y. -J.,Guo, Y. -Y.,Wang, Q.,Yang, S.,Zhang, Z..

作者其他论文 更多>>

微信小程序