Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.

文献类型： 外文期刊

第一作者： Yan, Xiao-Hui

作者： Yan, Xiao-Hui;Chen, Jia;Di, Ying-Tong;Fang, Xin;Wang, Yue-Hu;He, Hong-Ping;Hao, Xiao-Jiang;Yan, Xiao-Hui;Chen, Jia;Dong, Jia-Hong;Sang, Peng;Zhang, Zhong-Kai

作者机构：

关键词： Tobacco mosaic virus (TMV);Brucea javanica (L.) Merr.;quassinoids;structure-activity relationship (SAR).

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

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年卷期：

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收录情况： SCI

摘要： Two new quassinoids, javanicolide E (1) and javanicolide F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr. The antitobacco mosaic virus (TMV) activity of these quassinoids was screened by the conventional half-leaf and leaf-disk method along with Western blot analysis. All of the seventeen quassinoids showed potent anti-TMV activity. Among them, eight compounds, brusatol (3), bruceine B (4), bruceoslde B (5), yadanzioside I (6), yadanzioside L (7), bruceine D (8), yadanziolide A (9), and aglycone of yadanziolide D (17), showed strong antiviral activities, with IC_(50) values in the range of 3.42-5.66 μM, and were much more effective than the positive control, ningnanmycin (IC_(50) = 117.3 μM). The antiviral structure-activity relationships of quassinoids against TMV were also discussed.

分类号： R15

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