Effect of Mexel®432 on DNA Damage in Haliotis Discus Hannai and Mesocentrotus Nudus

文献类型： 外文期刊

第一作者： Zhang, Zhenglou

作者： Zhang, Zhenglou;Tao, Zheng;Cai, Jiaying;Sun, Ke;Miao, Zhengqiang;Liu, Xianling;Zhao, Shouxia;Jiang, Mei;Tang, Baojun;Li, Lei;Wang, Ye;Chen, Qiyi

作者机构：

关键词： Mexel (R) 432; DNA damage; single cell gel electrophoresis; comet assay

期刊名称：ISRAELI JOURNAL OF AQUACULTURE-BAMIDGEH （ 影响因子：0.4； 五年影响因子：0.5 ）

ISSN： 0792-156X

年卷期： 2024 年 76 卷 4 期

页码：

收录情况： SCI

摘要： Mexel (R) 432 is a surfactant-like substance that is a biosuppressant against marine fouling organisms. Therefore, to study the toxic effect of Mexel (R) 432 on marine organisms, the wrinkled abalone and echinococcus was exposed to concentrations of 0.175 mgL-1, 0.350 mgL-1, 0.700 mgL-1, 0.275 mgL-1, 0.550 mg center dot L-1, 1.100 mgL-1 Mexel (R) 432 solution, and single-cell gel electrophoresis (comet experiment) was used to detect different exposure times (0, 10, 20 d) DNA damage effect of digestive gland cells and echinococcus pallidae intestinal cells in wrinkled disc abalone, and tail DNA content, tail length, tail distance, and Olive tail distance were used as evaluation indexes. The results showed that different concentrations of Mexel (R) 432 could cause DNA disintegration and tailing in digestive gland cells and intestinal cells in a short period of time (10 d), and with the increase of Mexel (R) 432 concentration and the extension of exposure time, DNA deformation was obvious, the fragmentation increased, and the degree of damage was aggravated. When the concentration of Mexel (R) 432 reaches 0.350 mgL-1, it produces certain genotoxicity to the digestive gland cells of wrinkled abalone, and when the concentration of Mexel (R) 432 reaches 1.1000 mgL-1, it also has certain genotoxicity to the intestinal cells of Mesocentrotus nudus. The experimental results showed that Mexel (R) 432 had a significant dose effect relationship on DNA damage in the cells of two biological tissues.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序