Antitumor and immunomodulatory activity of arabinoxylans: A major constituent of wheat bran

文献类型: 外文期刊

第一作者: Zhou, Sumei

作者: Zhou, Sumei;Cao, Li;Liu, Xiuzhen;Qian, Tianxiu;Sun, Guibo;Guo, Yan;Chang, Fengjin;Sun, Xiaobo;Cao, Li;Liu, Xiuzhen;Qian, Tianxiu;Sun, Guibo;Guo, Yan;Chang, Fengjin;Sun, Xiaobo

作者机构:

关键词: Antitumor;Arabinoxylans;Immunomodulatory;S180 tumor mice;Wheat bran

期刊名称:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ( 影响因子:6.953; 五年影响因子:6.737 )

ISSN:

年卷期:

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收录情况: SCI

摘要: We aimed to investigate the antitumor activity of wheat bran arabinoxylans, including the role of its immunostimulatory effect. In S180 tumor-bearing mice arabinoxylan administration significantly inhibited the growth of mouse transplantable tumors and remarkably promoted thymus and spleen indexes, splenocyte proliferation, natural killer cell and macrophage phagocytosis activity, interleukin 2 production, and delayed-type hypersensitivity reaction. In addition, it increased peripheral leukocyte count, and bone-marrow cellularity in tumor-bearing mice. As the antitumor activity of arabinoxylans may be mediated via the improvement in the immune response, they can be considered an antitumor agent with immunomodulatory activity.

分类号: Q71

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