Pectin oligosaccharides from hawthorn (Crataegus pinnatifida Bunge. Var. major) inhibit the formation of advanced glycation end products in infant formula milk powder

文献类型： 外文期刊

第一作者： Zhu, Rugang

作者： Zhu, Rugang;Hong, Mengling;Zhuang, Chunyun;Zhang, Lijiao;Wang, Congya;Hu, Fengqing;Li, Tiejing;Ning, Chong;Zhu, Rugang;Duan, Zhenhua;Shang, Feifei;Liu, Jianli;Chen, Gang

作者机构：

期刊名称：FOOD & FUNCTION （ 影响因子：6.317； 五年影响因子：6.375 ）

ISSN： 2042-6496

年卷期： 2019 年 10 卷 12 期

页码：

收录情况： SCI

摘要： Pectin oligosaccharides (POSs) can not only be used as prebiotics to promote the growth of beneficial bacteria in the intestine but also can be used as natural food-borne antiglycation agents to inhibit the formation of advanced glycation end products (AGEs) in vitro, which is related to their structure, including molecular weight and galacturonic acid content. In this study, haw polysaccharides (HPSs) were isolated and purified, and POSs with high antiglycation activity in vitro were prepared. On this basis, the inhibitory effect of POSs on the formation of AGEs in infant formula milk powder was investigated. The results showed that no obvious inhibitory effect of POSs was found on the formation of AGEs in infant formula milk powder under accelerated storage at 25 degrees C and 45 degrees C. But, POSs showed a strong inhibitory effect on the formation of furosine, N-epsilon-carboxymethyllysine (CML), N-epsilon-carboxyethyllysine (CEL) and the total AGEs in infant formula milk powder under accelerated storage at 65 degrees C. In addition, POSs also had a strong inhibitory effect on the formation of lipid oxidation products but did not affect the formation of protein degradation products. Simultaneously, the cytotoxicity experiments using human umbilical vein endothelial cells showed that the infant formula milk powder supplemented with POSs had the lowest cytotoxicity compared to the blank control (BC) and GOS/FOS supplementation milk powder under accelerated storage at 65 degrees C, which may be related to the inhibitory effect of POSs on the formation of AGEs in infant formula milk powder. Furthermore, the in vitro fermentation experiments showed that the antiglycation process did not affect the prebiotic activity of POSs in infant formula milk powder.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序