Immunomodulatory activity in vitro and in vivo of polysaccharide from Potentilla anserina
文献类型: 外文期刊
第一作者: Chen, Jiong-Ran
作者: Chen, Jiong-Ran;Yang, Zhi-Qiang;Yan, Zuo-Ting;Wang, Ling;Cui, Dong-An;Hu, Ting-Jun;Niu, Ting-Xian;Wang, Meng
作者机构:
关键词: IFN-gamma: interferon-gamma;IL-10: interleukin-10;LDH: lactate dehydrogenase;lipopolysaccharide;concanavalin A: 11028-71-0;cyclophosphamide: 50-18-0;ACP;Potentilla anserina derived polysaccharide: immunologic-drug;immunostimulant-drug;cell proliferation;phagocytosis;immunomodulatory activity;immune parameter;immunosuppressed-model
期刊名称:FITOTERAPIA ( 影响因子:2.882; 五年影响因子:3.202 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: The polysaccharide (PAP) from Potentilla anserina was evaluated for modulating effects by using mouse peritoneal macrophage and the immunosuppressed-model cyclophosphamide-induced. Phagocytotic and mononuclear phagocytic system function assays showed that PAP stimulated the phagocytosis of phagocyte. Splenocyte proliferation assay showed that PAP acted the effect combining Con A or LPS in splenocyte proliferation. The parameters detected showed that PAP increased thymus and spleen indices, the levels of LDH and ACP in the spleen, and IL-10and IFN-gamma in serum in immunosuppressed mice. The results suggest that PAP is involved in immunomodulatory effects leading to the exploration for PAP as a potential immunostimulant
分类号: S759.82
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