Stereoselective determination of famoxadone enantiomers with HPLC-MS/MS and evaluation of their dissipation process in spinach

文献类型： 外文期刊

第一作者： Qian, Mingrong

作者： Qian, Mingrong;Wu, Liqin;Zhang, Hu;Li, Rui;Wang, Xiangyun;Chen, Zhimin;Wang, Jingwen

作者机构：

关键词： Enantioselectivity;Famoxadone;HPLC-MS/MS/dissipation

期刊名称：JOURNAL OF SEPARATION SCIENCE （ 影响因子：3.645； 五年影响因子：2.943 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： A simple and enantioselective method for the determination of famoxadone enantiomers in spinach using reversed-phase HPLC-MS/MS is presented. Famoxadone residues in spinach were extracted with acetonitrile and an aliquot was cleaned up with PSA (primary and secondary amine, Si-(CH2) 3-NH-(CH2)2-NH2) and C18 sorbent, which were powder material. Chiral stationary phase (CSP), cellulose tris(3,5-dimethylphenylcarbamate), was successfully applied to separate two enantiomers using methanol/formic acid-ammonium acetate buffer as mobile phase. The MS/MS fragmentation pathway of ammonium adduct famoxadone molecules ion at m/z 392 was analyzed and an odd electron fragment ion at m/z 238 was observed. Excellent linearity was achieved for each enantiomer over a range of concentrations from 0.5 to 1500 μg/L with coefficients more than 0.99. Average recoveries at five different levels (1, 2.5, 12.5, 250 and 1250 μg/kg, for each enantiomer) ranged from 80.8 to 96.5% with RSD of 4.8-13.4%. The famoxadone enantiomers LODs in spinach were determined to be both 0.3 μg/kg with LOQs of 1 μg/kg. Based on this method, the dissipation process of famoxadone enantiomers in spinach under open field and greenhouse conditions was characterized, providing guidance to the proper and safe use of this fungicide in agriculture.

分类号： O6

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