The porcine MUC20 gene: molecular characterization and its association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac

文献类型： 外文期刊

第一作者： Ji, Huayuan

作者： Ji, Huayuan;Ren, Jun;Yan, Xueming;Huang, Xiang;Zhang, Bo;Zhang, Zhiyan;Huang, Lusheng;Ji, Huayuan;Ren, Jun;Yan, Xueming;Huang, Xiang;Zhang, Bo;Zhang, Zhiyan;Huang, Lusheng;Ji, Huayuan;Yan, Xueming

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关键词： Pig;MUC20;Susceptibility;ETEC F4ab/ac

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）

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收录情况： SCI

摘要： Enterotoxigenic Eschoerchia coli (ETEC) F4 is a major cause of diarrhea in neonatal and young pigs. The locus encoding intestinal receptor for ETEC F4ab/ac has been mapped to pig chromosome (SSC) 13q41. We previously assigned mucin 20 (MUC20) to SSC13q41 and considered it a candidate for the ETEC F4ab/ac receptor. In this study, the full-length mRNA sequence of the porcine MUC20 gene was determined, revealing two MUC20 alternative transcripts differing in an 18-bp deletion in the open reading frame (ORF). The longer isoform is 1,927-bp long and contains a 1,572-bp ORF encoding a protein of 523 amino acids. RT-PCR analysis showed that MUC20 mRNA was expressed most highly in the kidney, prostate, epididymis and bladder. Seven single nucleotide polymorphisms in MUC20 were identified in founder animals of a White DurocErhualian cross, and the entire cross population (n=842) was genotyped for two MUC20 polymorphisms: g.191C>T in intron 5 and c.1600C>T in exon 6. The transmission disequilibrium test (TDT) results revealed that both polymorphisms were significantly associated with in vitro ETEC F4ab/ac adhesion phenotypes in the intercross population, and the most significant association was found between g.191C>T and F4ac adhesion phenotype (P=1.0210[ superscript]-9.

分类号： Q7

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