Phylogenetic analysis of infectious bronchitis coronaviruses newly isolated in China, and pathogenicity and evaluation of protection induced by Massachusetts serotype H120 vaccine against QX-like strains

文献类型： 外文期刊

第一作者： Sun, Chuyang

作者： Sun, Chuyang;Han, Zongxi;Ma, Huijie;Yan, Baolong;Shao, Yuhao;Xu, Jia;Kong, Xiangang;Liu, Shengwang;Zhang, Qinxia

作者机构：

关键词： Massachusetts serotype H120 vaccine: immunologic-drug;immunostimulant-drug;vaccine;genotype;genetic variation;clinical signs

期刊名称：AVIAN PATHOLOGY （ 影响因子：3.378； 五年影响因子：3.237 ）

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年卷期：

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收录情况： SCI

摘要： Seventy-eight isolates of avian infectious bronchitis virus (IBV) were obtained from different field outbreaks in China in 2009 and genotyped with 34 reference strains. Four genotypes of IBV and three new isolates were identified by phylogenetic analysis and BLAST searches of the entire S1 gene. The results showed that most IBV strains that have circulated in China in recent years belong to the genotype of QX-like strains, and that they could be grouped further into two clusters, regardless of the level of genetic variation displayed. A study of pathogenicity that used three QX-like strainsck/CH/LSD/091003, ck/CH/LDL/091022 and ck/CH/LJL/090330showed that the isolates caused the most severe lesions in the kidneys and were therefore nephropathogenic strains with various levels of virulence in specific pathogen free chickens. A vaccination-challenge test that was performed using the three QX-like strains showed that the commercially available H120 vaccine did not provide sufficient protection against challenge with the QX-like isolates, as demonstrated by comparison of the clinical signs, pathological lesions and virus recovery from the trachea and kidney of unvaccinated-challenged and vaccinated-challenged birds.

分类号： R36

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