The effects of fish oil plus vitamin D-3 intervention on non-alcoholic fatty liver disease: a randomized controlled trial

文献类型： 外文期刊

第一作者： Guo, Xiao-Fei

作者： Guo, Xiao-Fei;Wang, Chong;Yang, Ting;Ma, Wen-Jun;Li, Duo;Guo, Xiao-Fei;Wang, Chong;Yang, Ting;Ma, Wen-Jun;Li, Duo;Zhai, Jie;Zhao, Ting;Xu, Tong-Cheng;Li, Jun;Liu, He;Sinclair, Andrew J.;Li, Duo

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关键词： Fish oil; Vitamin D-3; Non-alcoholic fatty liver disease; Randomized controlled trial

期刊名称：EUROPEAN JOURNAL OF NUTRITION （ 影响因子：5.619； 五年影响因子：5.291 ）

ISSN： 1436-6207

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收录情况： SCI

摘要： Purpose The present study aimed to investigate fish oil plus vitamin D-3 (FO + D) supplementation on biomarkers of non-alcoholic fatty liver disease (NAFLD). Methods In a 3-month randomized controlled trial, 111 subjects with NAFLD, aged 56.0 +/- 15.9 y, were randomized into FO + D group (n = 37), fish oil group (FO, n = 37) or corn oil group (CO, n = 37). The subjects consumed the following capsules (3 g/day), which provided 2.34 g/day of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) + 1680 IU vitamin D-3 (FO + D group), or 2.34 g/day of EPA + DHA (FO group), or 1.70 g/d linoleic acid (CO group). Results Using multivariable-adjusted general linear model, there were significant net reductions in serum alanine aminotransferase (ALT), and triacylglycerol (TAG) and TNF-alpha levels in the FO + D and FO groups, compared with the control group (P < 0.05). The supplemental FO + D also showed significant reductions in insulin (- 1.58 +/- 2.00 mU/L vs. - 0.63 +/- 1.55 mU/L, P = 0.050) and IL-1 beta (- 6.92 +/- 7.29 ng/L vs. 1.06 +/- 5.83 ng/L, P < 0.001) in comparison with control group. Although there were no significant differences between FO + D and FO groups regarding biochemical parameters, supplemental FO + D showed decreases in ALT (from 26.2 +/- 13.5 U/L to 21.4 +/- 9.6 U/L, P = 0.007), aspartate aminotransferase (AST, from 22.5 +/- 7.0 U/L to 20.2 +/- 4.0 U/L, P = 0.029), HOMA-IR (from 3.69 +/- 1.22 to 3.38 +/- 1.10, P = 0.047), and TNF-alpha (from 0.43 +/- 0.38 ng/L to 0.25 +/- 0.42 ng/L, P < 0.001) levels following the intervention. Conclusion The present study demonstrated that groups supplemented with FO + D and FO had similar beneficial effects on biomarkers of hepatocellular damage and plasma TAG levels in subjects with NAFLD, while in the FO + D group, there were some suggestive additional benefits compared with FO group on insulin levels and inflammation.

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