Risk Assessment of Chlorothalonil as a Probable Human Carcinogen on Selected Vegetables in an Eastern China Province

文献类型： 外文期刊

第一作者： Sun, Chen-Xi

作者： Sun, Chen-Xi;Wang, Wen-Bo;Yuan, Xue-Xia;Wu, Yuan-Juan;Liu, Bing

作者机构：

关键词： chlorothalonil; carcinogenic risk assessment; pesticide residue; public health; Monte-Carlo simulation

期刊名称：FRONTIERS IN PUBLIC HEALTH （ 影响因子：6.461； 五年影响因子：6.002 ）

ISSN：

年卷期： 2022 年 10 卷

页码：

收录情况： SCI

摘要： ObjectivesThis study aimed to provide an assessment of chlorothalonil's possible carcinogenic risk posed to the public. In combination and comparison with the non-carcinogenic risk, the results hopefully could provide useful insights, early warning, and references for policy formulation. MethodsThis study firstly investigated the occurrence of chlorothalonil on selected key vegetables for different scenarios, and then conducted an exposure assessment with officially published data. Lastly, both the non-carcinogenic and carcinogenic risk of chlorothalonil were calculated by using Monte-Carlo simulation. ResultsEven though mean non-carcinogenic risks of chlorothalonil for all scenarios were below threshold value, the mean carcinogenic risks for maximum-risk scenario and most-likely risk scenario were mostly above threshold value. High probabilities of exceedance of threshold value existed for carcinogenic risk under all scenarios. ConclusionPotential threat to public health existed for conventionally 'safe' pesticide if considering the possible carcinogenicity. Extra caution should be taken and the potential carcinogenic effects should be included into consideration for better protection of public health during the policy formulation process.

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