Purple-Grain Wheat Regulation of Blood Lipids and Blood Glucose in Diet-Induced Hyperlipidemic Mice and Type 2 Diabetic Mice

文献类型： 外文期刊

第一作者： Hu, Dong

作者： Hu, Dong;Cheng, Shasha;Man, Chaoxin;Hu, Dong;Wei, Xiaoyan

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关键词： purple-grain wheat; glucolipid level; hyperlipidemia; type 2 diabetes

期刊名称：NUTRIENTS （ 影响因子：5.0； 五年影响因子：6.0 ）

ISSN：

年卷期： 2025 年 17 卷 8 期

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收录情况： SCI

摘要： Background/Objectives: Disorders of glucose and lipid metabolism can easily lead to metabolic diseases such as hyperlipidemia and diabetes mellitus, with multiple complications. This study evaluated the regulatory effect of purple-grain wheat on glycolipid metabolism. Methods: In this study, we established a hyperlipidemic mouse model by means of a high-fat diet and a type 2 diabetic mouse model using a high-fat and high-sugar diet combined with streptozotocin, and the mice were intervened with 15 g/(kgd), 7.5 g/(kgd), and 3.75 g/(kgd) doses of purple-grain wheat paste (PWP) for 4 and 5 weeks, respectively. Results: The results revealed that PWP reversed the increase in body weight; increased serum high-density lipoprotein cholesterol; and decreased serum total cholesterol, triglycerides, and low-density lipoproteins. In addition, PWP reversed the decrease in body weight and alleviated the sustained increase in blood glucose in type 2 diabetic mice. Conclusions: PWP shows a significant ability to regulate glycolipid levels, which is related to its functional composition and its ability to act as a prebiotic. In conclusion, PWP can be considered a potential functional food for lowering blood glucose and blood lipids.

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