Differential gene expression drives muscle metabolic and structural differences in Liang Guang small spotted vs. large white pigs

文献类型： 外文期刊

第一作者： Feng, Zheng

作者： Feng, Zheng;Wang, Wen-Jing;Wang, Nan;Chi, Shun-Shun;Mu, Yu-Lian;Liu, Zhi-Guo

作者机构：

关键词： Longissimus dorsi muscle; Whole-transcriptome sequencing; RNA sequencing; Pig; Liang Guang Small Spotted pigs

期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.9； 五年影响因子：4.3 ）

ISSN： 2045-2322

年卷期： 2025 年 15 卷 1 期

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收录情况： SCI

摘要： The Liang Guang Small Spotted (LGSS) pigs, an indigenous Chinese breed, are reported to exhibit desirable muscle attributes such as high intramuscular fat deposition, smaller muscle fiber diameter, and superior water-holding capacity. However, despite these merits, its commercial utility is constrained by suboptimal growth rates and diminished carcass yield. To explore transcriptomic differences potentially associated with distinct muscle phenotypes and identify targets for productivity enhancement, we performed integrated transcriptomic analysis of longissimus dorsi muscles (LDMs) from LGSS and Large White (LW) pigs. We characterized differentially expressed (DE) mRNAs, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), which were primarily enriched in key biological processes including glycolysis and carbon metabolism, structural organization, as well as signaling cascades such as HIF-1, AMPK, and PI3K-Akt. This study uncovers significant transcriptomic distinctions and identifies candidate regulatory molecules in LGSS pigs, offering potential biomarkers and a framework for future functional studies aimed at genetic improvement.

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