Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro

文献类型： 外文期刊

第一作者： Cui, Zhanding

作者： Cui, Zhanding;Li, Zhiyong;Cui, Zhanding;Zhao, Shihui;Zhang, Qian;Tan, Yuxin;Shao, Jiang;Zhang, Shuang;Huang, Hailong;Wang, Junzheng;Pei, Zhihua;Wang, Kai;Hu, Guixue;Li, Zhiyong;Wang, Qian;Li, Dengliang;Liu, Ting;Dong, Hao

作者机构：

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

ISSN： 0304-8608

年卷期： 2021 年 166 卷 9 期

页码：

收录情况： SCI

摘要： Cats infected with feline calicivirus (FCV) often display oral ulcers and inflammation of the upper respiratory tract, which can lead to death in severe cases. Antiviral therapy is one of the most effective ways to control FCV infection. Natural compounds in Chinese herbal medicines and medicinal plants provide abundant resources for research on antiviral drugs. In this study, we found that icariin (ICA), formononetin (FMN) and caffeic acid phenethyl ester (CPAE) show low cytotoxicity towards F81 cells, that the three natural compounds have apparent antiviral effects on FCV in vitro, and that they can inhibit different FCV strains. Then, we found that ICA and FMN mainly function in the early stage of FCV infection, while CAPE can function in both the early and late stages of FCV infection. Finally, we found that ICA has an antagonistic effect on FMN and CAPE in FCV infection, and FMN has a synergistic effect with CAPE against FCV infection. Our results showed that ICA, FMN and CAPE may be potential drug candidates for FCV-induced diseases.

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