文献类型： 外文期刊
第一作者： Tang, Yan-Dong
作者： Tang, Yan-Dong;Cai, Xue-Hui;Yin, Xin;Tang, Yan-Dong;Tang, Yan-Dong;Li, Yuming;Li, Yuming
作者机构：
关键词： adaptation; attenuation; evolution; live attenuated vaccines (LAVs); pathogenicity
期刊名称：ADVANCED SCIENCE （ 影响因子：14.1； 五年影响因子：15.6 ）
ISSN：
年卷期： 2025 年 12 卷 3 期
页码：
收录情况： SCI
摘要： Viral infections continue to pose a significant threat to the health of both humans and animals. Currently, live attenuated vaccines (LAVs) remain the most efficacious and widely utilized tool for combating viral infections. Conventional LAVs involve the adaptation of virulent viruses to novel hosts, cell cultures, or suboptimal environments, resulting in a reduction in pathogenicity while retaining immunogenicity. This process entails directed evolution of the virus to enhance its replication efficiency under these modified conditions. In this review, the development of traditional animal-adapted and cold-adapted LAVs is specially discussed. Additionally, the factors that contribute to virus attenuation from a viral lifecycle perspective are summarized. Finally, we propose future directions for next-generation LAVs.
分类号：
- 相关文献
作者其他论文 更多>>
-
Icariin-loaded chitosan/β-glycerophosphate thermosensitive hydrogel enhanced infection control and bone regeneration in canine with infectious bone defects
作者：Shao, Bing;Fu, Yang;Li, Bo;Huo, Siming;Du, Jiayu;Zhang, Xuliang;Li, Yanfei;Cao, Zheng;Song, Miao;Fu, Yang;Shao, Bing;Yin, Xin
关键词：Icariin; thermosensitive hydrogel; infection control; angiogenesis; bone regeneration
-
Palmitoylation- dependent association with Annexin II directs hepatitis E virus ORF3 sorting into vesicles and quasi- enveloped virions
作者：Liu, Xing;Shao, Zhen;Xiong, Xiaoyan;Qi, Shuhui;Guan, Junyong;Wang, Menghang;Tang, Yan-Dong;Yin, Xin;Liu, Tianxu;Wang, Lin;Liu, Tianxu;Wang, Lin;Xiong, Xiaoyan;Feng, Zongdi;Feng, Zongdi
关键词：hepatitis E virus; |ORF3 vesicle; exosome; quasi- enveloped virus; assembly
-
The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2
作者：Bai, Yuan-Zhe;Wang, Shujie;Sun, Yue;Liu, Yong-Gang;Zhang, Hong-Liang;Wang, Qian;Huang, Rui;Rao, Cui-Hong;Xu, Shi-Jia;Tian, Zhi-Jun;An, Tong-Qing;Cai, Xue-Hui;Tang, Yan-Dong;Cai, Xue-Hui;Tang, Yan-Dong;Tang, Yan-Dong
关键词：arterivirus; PRRSV; nsp2; assembly; glycoprotein (GP); nucleocapsid (N) protein
-
The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection?
作者：Na, Lei;Zheng, Yang;Yang, Jian-Bo;Bao, Hao-Lin;Tang, Yan-Dong
关键词：
-
Epidemiological, virological, and pathogenic insights into Nairobi sheep disease virus infection in sheep and goats in China
作者：Yao, Xin-Yan;Zhang, Xue-Lian;Zhang, Xu;Lian, Chun-Yang;Lv, Zhi-Hang;Shao, Jian-Wei;Wang, Meng-Hang;Liang, De-Xin;Li, Shao-Han;Xia, Chang-You;Yang, Ming-fa;Yin, Xin
关键词：Nairobi sheep disease virus; identification; epidemiology; virus isolation; pathogenic characterization; sheep and goats
-
LC/MS and MALDI-MSI reveal the different distribution of terpenoids in Glycine max and Glycine soja seeds
作者：Yu, Qi;Ren, Zhentao;Liu, Laipan;Zhang, Li;Yin, Xin;Shen, Wenjing;Fang, Zhixiang;Liu, Biao;Jia, Ruizong;Liu, Biao
关键词：Soybeans; Terpenoids; Metabolomics; Flavor; Stress resistance
-
Pseudorabies virus gM protein and herpesvirus homologs block selective autophagy to enhance viral replication
作者：Zhou, Qiongqiong;Tang, Yan-Dong;Zhang, Longfeng;Liu, Hongyang;Ye, Guangqiang;Zhang, Zhaoxia;Huang, Li;Weng, Changjiang;Zhou, Qiongqiong;Tang, Yan-Dong;Zhang, Zhaoxia;Huang, Li;Weng, Changjiang;Shi, Deshi;Hu, Boli
关键词：Caspase 3; gM homologs; inhibit autophagic flux; macroautophagy; protein aggregates; SNAP29
