A naturally occurring SNP modulates thermotolerance divergence among grapevines

文献类型： 外文期刊

第一作者： Chen, Haiyang

作者： Chen, Haiyang;Yu, Haibo;Kong, Lingchao;Li, Shenchang;Li, Yang;Wang, Yi;Duan, Wei;Dai, Zhanwu;Fan, Peige;Li, Shaohua;Liang, Zhenchang;Wang, Lijun;Chen, Haiyang;Yu, Haibo;Kong, Lingchao;Li, Shenchang;Li, Yang;Wang, Yi;Duan, Wei;Dai, Zhanwu;Fan, Peige;Li, Shaohua;Liang, Zhenchang;Wang, Lijun;Chen, Haiyang;Chen, Haiyang;Yu, Haibo;Kong, Lingchao;Li, Shenchang;Dai, Zhanwu;Fan, Peige;Liang, Zhenchang;Wang, Lijun;Yuan, Ling;Yuan, Ling;Cao, Xiongjun;Lin, Ling;Guo, Rongrong;Xie, Taili

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

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年卷期： 2025 年 16 卷 1 期

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收录情况： SCI

摘要： With the increasing challenges posed by global warming and climate change, heat stress has become a significant threat to the sustainable production of grapevines. However, the genetic basis of grapevine thermotolerance remains poorly understood. Here, we combine genome-wide association study with transcriptomic profiling to identify TTC4 (thermotolerance on chromosome 4), a gene encoding a WRKY transcription factor, as a key determinant of thermotolerance in grapevine. TTC4 directly activates two thermotolerance-related genes, HSP18.1 and APX3. We also identify a heat-suppressed repressor SPL13 (SQUAMOSA-promoter binding protein-like 13) that cannot bind to the GTAT element (TTC4T(7631)) in intron 2 of TTC4, but can bind to the natural variant, GTAC (TTC4C(7631)). Grapevine accessions with TTC4C/C(7631) genotype exhibit significantly lower thermotolerance compared to those with the TTC4T/T(7631) and TTC4C/T(7631) genotypes. This fine-tuned regulation contributes to thermotolerance divergence among grapevine populations. The TTC4T(7631) haplotype holds significant potential as a genetic resource for breeding thermotolerant grapevine varieties.

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