Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models
文献类型： 外文期刊
第一作者： Liu, Xiaowei
作者： Liu, Xiaowei;Han, Ying;Xiao, Ouli;Chen, Jieyin;Dai, Xiaofeng;Kong, Zhiqiang;Liu, Xiaowei;Chen, Jieyin;Dai, Xiaofeng;Kong, Zhiqiang;Cui, Weiye;Li, Minmin
作者机构：
关键词： grape; fungicide; in vitro model; bioaccessibility; Caco-2 cells
期刊名称：FOODS （ 影响因子：5.561； 五年影响因子：5.94 ）
ISSN：
年卷期： 2022 年 11 卷 23 期
页码：
收录情况： SCI
摘要： In this study, the effects of various digestive models, influencing factors and dietary supplements on the bioaccessibility of tebuconazole in table grapes were compared. The Caco-2 cell model was employed to reveal the transfer behavior of tebuconazole. The results indicated that digestion time is the main factor affecting bioaccessibility. With an increase in time, the tebuconazole in grapes was almost completely dissolved, with bioaccessibility reaching 98.5%, whereas dietary fiber reduced bioaccessibility. Tebuconazole undergoes carrier-free passive transport in permeable cells in the Caco-2 cell model. These findings have practical application value for correctly evaluating the harmful level of pollutants in the matrix to human body.
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