Comparative Analysis of Cross-Protective Immunity Among Three Geographically Distinct Isolates of Eimeria kongi
文献类型： 外文期刊
第一作者： Fang, Sufang
作者： Fang, Sufang;Meng, Linghai;Hao, Chengyu;Gu, Xiaolong;Du, Fangchen;Cui, Ping;Shi, Yubo;Tang, Xinming
作者机构：
关键词：
rabbit coccidiosis;
期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）
ISSN： 2076-2615
年卷期： 2024 年 14 卷 23 期
页码：
收录情况： SCI
摘要： Coccidiosis is one of the most significant diseases affecting the rabbit industry and is caused by Eimeria. In a previous study, we identified a new species of Eimeria kongi (E. kongi-ZJK) from the northern region of China (Zhangjiakou, Hebei Province) and studied its pathogenicity and immunogenicity. The aim of this study was to evaluate the pathogenicity, immunogenicity, and cross-immunogenicity from different geographical isolates of E. kongi for vaccine development. Two geographical isolates of E. kongi-QD from Qingdao, Shandong Province (eastern China), and E. kongi-CD from Chengdu, Sichuan Province (southwestern China), were isolated and identified. The pathogenicity, immunogenicity, and cross-immunogenicity among the three geographical isolates were evaluated. The pathogenicity results showed that after infecting rabbits with doses of 1 x 103 or fewer sporulated oocysts of E. kongi-QD and E. kongi-CD, the rabbits exhibited clinical symptoms but recovered quickly, indicating lower pathogenicity. Immunogenicity studies revealed that after immunizing rabbits with 1 x 103 sporulated oocysts of E. kongi-QD and E. kongi-CD for 14 days, followed by challenge with 1 x 104 homologous sporulated oocysts, the oocyst reduction rates in the immunized groups were 99.39% and 99.12%, respectively, compared with the non-immunized groups, demonstrating good immunogenicity. In cross-immunogenicity studies, rabbits were immunized with 1 x 103 sporulated oocysts of E. kongi-ZJK, E. kongi-QD, or E. kongi-CD and then challenged with 1 x 104 sporulated oocysts of heterologous isolate. The immunized groups showed no significant clinical symptoms, and the oocyst reduction rates ranged from 55.9% to 98.4%. E. kongi-CD exhibited cross-protection against E. kongi-ZJK and E. kongi-QD, making it an ideal candidate formulation for vaccine development.
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