Development of Acid Hydrolysis-Based UPLC-MS/MS Method for Determination of Alternaria Toxins and Its Application in the Occurrence Assessment in Solanaceous Vegetables and Their Products

文献类型： 外文期刊

第一作者： Tang, Hongxia

作者： Tang, Hongxia;Han, Wei;Fei, Shaoxiang;Li, Yubo;Huang, Jiaqing;Dong, Maofeng;Wang, Weimin;Dong, Maofeng;Wang, Lei;Zhang, Ying

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关键词： Alternaria toxins; modified analytical method; solanaceous vegetables; solanaceous vegetable products; UPLC-MS; MS

期刊名称：TOXINS （ 影响因子：4.2； 五年影响因子：4.7 ）

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年卷期： 2023 年 15 卷 3 期

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收录情况： SCI

摘要： In this work, we proposed an acid hydrolysis-based analytical method for the detection of Alternaria toxins (ATs) in solanaceous vegetables and their products with solid-phase extraction (SPE) and ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This study was the first to reveal that some compounds in the eggplant matrix bind to altenusin (ALS). Validation under optimal sample preparation conditions showed that the method met the EU criteria, exhibiting good linearity (R-2 > 0.99), matrix effects (-66.6--20.5%), satisfying recovery (72.0-107.4%), acceptable precision (1.5-15.5%), and satisfactory sensitivity (0.05-2 mu g/kg for limit of detection, 2-5 mu g/kg for limit of quantification). Out of 393 marketed samples, only 47 samples were detected, ranging from 0.54-806 mu g/kg. Though the occurrence ratio (2.72%) in solanaceous vegetables could be negligible, the pollution status in solanaceous vegetable products was much more serious, and the incidences were 41.1%. In the 47 contaminated samples, the incidences were 4.26% for alternariol monomethyl ether (AME), 6.38% for alternariol (AOH) and altenuene (ALT), 42.6% for tentoxin (TEN), and 55.3% for tenuazonic acid (TeA).

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